Our Approach

Cancer cells often have altered proteasome functions, which can contribute to their uncontrolled growth and survival.
Multi-year research at Prof. Ciechanover’s Laboratory unveiled a novel mechanism of action related to the dynamics of proteasome localization and distribution in cells.

Proteasomes can move between the nucleus and the cytoplasm and this translocation is mediated by a specific signal.

The ground-breaking research conducted by Prof. Ciechanover’s Laboratory sheds new light on the dynamics of proteasome localization in cells and leads to new treatment options for cancer patients.